GHK-Cu

Technical specifications

Molecular weight

340.38 Da (Cu complex)

Sequence

Gly-His-Lys · Cu²⁺

Format

Sterile lyophilized

Content

50 mg per vial

Purity

≥99% verified by HPLC in batch CoA

Appearance

Characteristic blue crystalline powder

Identity

Confirmed by MS and atomic absorption of Cu

Endotoxins (LAL)

< 5 EU/mg

Water content (Karl Fischer)

< 6%

Amino acid analysis

Composition confirmed by acid hydrolysis

About GHK-Cu 50 mg

Research applications

In preclinical in vitro models, the complex stimulates type I and III collagen synthesis in dermal fibroblasts, inhibits the expression of matrix metalloproteinases (MMPs) associated with tissue damage, and modulates the cellular antioxidant response. The copper ion (Cu²⁺) coordinated to the tripeptide contributes enzymatic cofactor activity for superoxide dismutase (SOD), one of the primary endogenous antioxidant systems [2][3]. The copper:peptide stoichiometric ratio is verified analytically to ensure the integrity of the bioactive complex in every batch.

Storage and handling

Sealed vial of GHK-Cu 50 mg: protect from direct light, humidity, and prolonged air exposure to preserve the integrity of the copper-peptide complex, which is chemically sensitive to oxidation. Once the experimental solution is prepared, keep refrigerated under documented conditions with strict records of opening date, diluent used, and workstation conditions. As a sensitive copper-peptide complex, repeated freeze-thaw cycles of the prepared solution are not recommended; apply the institutional criteria defined in the lab's SOP. Discard the material at any change in color from the original blue crystalline appearance, turbidity, or the appearance of particles.

Scientific references

1. [1]Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed 2008; 19(8):969–988. View source on PubMed →
2. [2]Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide. Oxid Med Cell Longev 2018; Article ID 7591840. View source on PubMed →
3. [3]Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Res Int 2015. View source on PubMed →

Frequently asked questions

• What's included in the GHK-Cu 50 mg vial?+

  A sterile lyophilized vial containing 50 mg of the GHK-Cu complex (glycyl-L-histidyl-L-lysine tripeptide coordinated with copper Cu²⁺), recognizable by its characteristic blue crystalline powder, shipped with the batch Certificate of Analysis (CoA).

• Why is the powder blue?+

  Because of the coordination of the Cu²⁺ ion with the GHK tripeptide, which produces the characteristic bioactive copper-peptide complex. The blue crystalline color is a visual indicator of complex integrity; any color change indicates oxidation or degradation.

• How do I verify the copper:peptide stoichiometry?+

  The CoA reports the copper content by atomic absorption, in addition to peptide purity ≥99% by HPLC and identity by ESI-MS. The stoichiometric ratio conditions the analytical bioactivity of the complex in in vitro studies.

• How should the solution be stored after preparation?+

  Under documented refrigeration with strict records of opening date, diluent, and conditions. Do not freeze-thaw repeatedly. Discard at any color change from the original blue crystalline appearance, turbidity, or suspended particles.

• Is it legal in Mexico, and what is it distributed for?+

  Yes, as a scientific research compound for experimental in vitro use. It is not distributed as a cosmetic, medication, supplement, or consumer product. The receiving lab's institutional SOP defines the protocols.

• How long does shipping take, and is there free shipping?+

  1–4 business days depending on destination within Mexico (1–2 north, 2–3 center, 3–4 south) via Estafeta, FedEx, or DHL, with UV-protective insulating packaging. Free shipping on orders over $2,000 MXN. We do not ship internationally.