MOTS-c

Technical specifications

Molecular weight

2,174.62 Da

Sequence

MRWQEMGYIFYPRKLR (16 aa)

Format

Sterile lyophilized

Content

10 mg per vial

Purity

≥99% verified by HPLC in batch CoA

Identity

Confirmed by MALDI-TOF MS

Genomic origin

Mitochondrial DNA (12S rRNA)

Endotoxins (LAL)

< 5 EU/mg

Water content (Karl Fischer)

< 6%

Amino acid analysis

Composition confirmed by acid hydrolysis

About MOTS-c 10 mg

Research applications

In preclinical in vitro and in vivo rodent models, MOTS-c is associated with activation of AMPK (AMP-activated protein kinase), the cell's master energy sensor, per the original characterization published by Lee et al. in Cell Metabolism [1]. Modulation of the folate metabolism pathway and regulation of metabolic homeostasis are also documented in the foundational paper and the follow-up by Reynolds et al. in Nature Communications [2], which reports exercise-dependent regulation of the peptide in animal models with age-associated physical decline. The specific experimental application is the responsibility of the receiving lab and its authorized institutional SOP.

Storage and handling

Sealed vial of MOTS-c 10 mg: store in a controlled environment, protected from humidity, direct light, and thermal variation. Once the experimental solution is prepared with the diluent specified in the lab's SOP, keep refrigerated under documented conditions when the protocol requires it and avoid repeated freeze-thaw cycles. Discard the material at any sign of turbidity, suspended particles, or loss of the original lyophilized appearance.

Scientific references

1. [1]Lee C et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis. Cell Metabolism 2015; 21(3):443–454. View source on PubMed →
2. [2]Reynolds JC et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. Nature Communications 2021; 12:470. View source on PubMed →

Frequently asked questions

• What's included in the MOTS-c 10 mg vial?+

  A sterile lyophilized vial containing MOTS-c 10 mg (synthetic 16-amino-acid peptide, sequence MRWQEMGYIFYPRKLR), shipped with the batch-specific Certificate of Analysis (CoA) — the batch number on the vial is auditable against the independent analytical lab.

• What purity is guaranteed?+

  ≥99% verified by high-resolution reverse-phase HPLC with full chromatogram. Identity is confirmed by MALDI-TOF MS, and amino-acid, water (Karl Fischer), and endotoxin (LAL) controls are also reported.

• Why is MOTS-c considered a mitochondrial peptide?+

  Because its sequence is encoded inside human mitochondrial DNA, within the 12S rRNA gene reading frame. It is one of the first mitochondrial-derived peptides characterized with systemic hormonal function, discovered by Lee and colleagues in Cell Metabolism (2015).

• How should the sealed vial be stored?+

  Store in a controlled environment, protected from humidity, direct light, and thermal variation due to the peptide's sensitivity. Stability of prepared solutions depends on the specific CoA, the SOP diluent, and the receiving lab's institutional protocol. Avoid repeated freeze-thaw cycles.

• Is it legal to buy MOTS-c in Mexico?+

  Yes, as a scientific research compound for experimental use in vitro and in authorized preclinical models. It is not a medication, supplement, or consumer product, and it is not approved by COFEPRIS for those uses.

• How long does shipping take, and is there free shipping?+

  1–4 business days depending on destination within Mexico (1–2 north, 2–3 center, 3–4 south) via Estafeta, FedEx, or DHL. Free shipping on orders over $2,000 MXN. We do not ship internationally.

• Where can I buy MOTS-c in Mexico?+

  MX-1 Labs distributes MOTS-c for scientific research throughout Mexico: ≥99% purity verified by HPLC, a batch-specific Certificate of Analysis (CoA) with an auditable lot number, and nationwide shipping from CDMX in 1–4 business days. For laboratory research only; not for human consumption.